Redefining Muscle Therapy with Science
Harnessing the power of cutting-edge research to develop transformative therapies for muscle-wasting diseases.
Science Behind Sarcomatrix
Our Scientific Innovations
Scientific breakthroughs transforming how we treat
muscle loss and degeneration.
Extracellular Matrix (ECM)
The ECM supports muscle development by guiding cell behavior, while α7β1 integrin connects myocytes to laminin for stability and growth.
- ECM supports muscle cell migration, growth, and differentiation.
- 7β1 integrin connects muscle cells to the ECM.
- Links myocytes to laminin for stability.
- Regulates muscle formation and repair.
Laminin
Laminin stabilizes muscle fibers, regulates growth, and maintains membrane integrity.
- Stabilizes muscle fibers within the ECM.
- Regulates muscle differentiation, migration, and growth.
- Maintains the basement membrane structure.
- Essential for muscle development and health.
α7β1 Integrin
α7β1 integrin links muscle cells to the ECM, supporting growth, migration, and integrity by connecting to laminin.
- Connects muscle cells to ECM for stability.
- Supports growth, migration, and differentiation.
- Maintains muscle integrity via laminin.
- Essential for muscle function.
S-969
S-969 enhances α7 integrin expression, aiding muscle regeneration in aging, chemotherapy, and muscular diseases.
- Boosts α7 integrin for muscle health.
- Developed with NIH for therapy.
- Targets muscle loss from disease and aging.
- Lead compound among α7β1 activators.
Sunitinib
Sunitinib, an FDA-approved drug, enhances α7 integrin, promoting muscle repair by activating satellite cells.
- FDA-approved for muscle regeneration.
- Enhances α7 integrin for repair.
- Activates satellite cells and fusion.
- Works via STAT3 activation.
LAM 111
LAM-111 is a potential therapy for LAMA2-RD, replacing defective laminin to support muscle function.
- Therapy for congenital muscular dystrophy.
- Replaces defective laminin.
- Supports muscle structure and function.
- No approved treatments available.
Putting It All Together
α7β1 integrin and laminin are key to muscle health, and their disruption leads to degeneration and weakness.
- Crucial for muscle stability and repair.
- Disruptions cause muscle loss.
- Key targets for new therapies.
- Maintain ECM and cell interaction.
